Bei Lungenerkrankungen wie der COPD kann sich eine Schw\u00c3\u00a4che der Zwerchfellmuskulatur entwickeln und die k\u00c3\u00b6rperliche Leistungsf\u00c3\u00a4higkeit erheblich einschr\u00c3\u00a4nken. Es wurde in einer Studie mit 30 gesunden Probanden gepr\u00c3\u00bcft, wie sich die Gabe eines sogenannten Calciumsensibilisierers (in diesem Fall Levosimendan) nach hoher Belastung des Zwerchfells auswirkt. Dies f\u00c3\u00bchrte unter Placebo zu einen 9%-igem Verlust der Muskelkraft, unter Levosimendan trat kein Abfall auf.<\/p>\n
Die Studie zeigt einen interessanten Ansatz zum Erhalt der Atmungsmuskelleistung. Es fehlen aber noch Untersuchungen zur Wirkung bei Erkrankten, und zu kurz- und l\u00c3\u00a4ngerfristigen m\u00c3\u00b6glicherweise auftretenden Nebenwirkungen. (Doorduin J et al. Amer J Resp Crit Care Med 2012; 185: 90-95)<\/p>\n","protected":false},"excerpt":{"rendered":"
Bei Lungenerkrankungen wie der COPD kann sich eine Schw\u00c3\u00a4che der Zwerchfellmuskulatur entwickeln und die k\u00c3\u00b6rperliche Leistungsf\u00c3\u00a4higkeit erheblich einschr\u00c3\u00a4nken. Es wurde in einer Studie mit 30 gesunden Probanden gepr\u00c3\u00bcft, wie sich die Gabe eines sogenannten Calciumsensibilisierers (in diesem Fall Levosimendan) nach hoher Belastung des Zwerchfells auswirkt. Dies f\u00c3\u00bchrte unter Placebo zu einen 9%-igem Verlust der Muskelkraft, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-322","post","type-post","status-publish","format-standard","hentry","category-allgemein"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"hein","author_link":"https:\/\/dr-holger-hein.de\/reloaded\/author\/hein\/"},"uagb_comment_info":0,"uagb_excerpt":"Bei Lungenerkrankungen wie der COPD kann sich eine Schw\u00c3\u00a4che der Zwerchfellmuskulatur entwickeln und die k\u00c3\u00b6rperliche Leistungsf\u00c3\u00a4higkeit erheblich einschr\u00c3\u00a4nken. Es wurde in einer Studie mit 30 gesunden Probanden gepr\u00c3\u00bcft, wie sich die Gabe eines sogenannten Calciumsensibilisierers (in diesem Fall Levosimendan) nach hoher Belastung des Zwerchfells auswirkt. Dies f\u00c3\u00bchrte unter Placebo zu einen 9%-igem Verlust der Muskelkraft,…","_links":{"self":[{"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/posts\/322","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/comments?post=322"}],"version-history":[{"count":0,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/posts\/322\/revisions"}],"wp:attachment":[{"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/media?parent=322"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/categories?post=322"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/tags?post=322"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}