{"id":1542,"date":"2026-07-11T13:42:23","date_gmt":"2026-07-11T11:42:23","guid":{"rendered":"https:\/\/dr-holger-hein.de\/reloaded\/?p=1542"},"modified":"2026-07-11T13:42:23","modified_gmt":"2026-07-11T11:42:23","slug":"tagesschlaefrigkeit-und-physiologische-endotypen-der-schlafapnoe-mesa-studie","status":"publish","type":"post","link":"https:\/\/dr-holger-hein.de\/reloaded\/2026\/07\/11\/tagesschlaefrigkeit-und-physiologische-endotypen-der-schlafapnoe-mesa-studie\/","title":{"rendered":"Tagesschl\u00e4frigkeit und physiologische Endotypen der Schlafapnoe (MESA-Studie)"},"content":{"rendered":"\u00dcberm\u00e4\u00dfige Tagesschl\u00e4frigkeit (EDS) ist bei obstruktiver Schlafapnoe (OSA) ist mit bestimmten physiologischen Endotypen assoziiert und unterscheidet sich zwischen M\u00e4nnern und Frauen. In der bev\u00f6lkerungsbasierten Multi-Ethnic Study of Atherosclerosis (MESA) wurden 1783 Teilnehmer mit einem AHI > 5\/h (mittleres Alter 68,7 \u00b1 9,1 Jahre, 52 % Frauen) mittels Polysomnographie, Aktigraphie und Epworth-Schl\u00e4frigkeitsskala (ESS) untersucht. 14 % der Stichprobe wiesen eine EDS (ESS > 10) auf. Ein Anstieg der hypoxischen Last (Hypoxic Burden) um eine Interquartilsspanne war mit einer 28 % h\u00f6heren Pr\u00e4valenz von EDS assoziiert (PR 1,28), ebenso ein erh\u00f6hter Loop Gain (PR 1,26) und eine st\u00e4rkere Herzfrequenzreaktion auf Atemereignisse (PR 1,32). In geschlechtsspezifischen Analysen zeigte sich bei Frauen ein Zusammenhang zwischen EDS und k\u00fcrzerer Ereignisdauer sowie h\u00f6herer neuromuskul\u00e4rer Kompensation, w\u00e4hrend bei M\u00e4nnern die hypoxische Last und die Herzfrequenzreaktion st\u00e4rker mit EDS assoziiert waren. Erregungsschwelle (Arousal Threshold) und Erregungsintensit\u00e4t zeigten keine Assoziation mit EDS. Die Befunde zeigen, dass EDS bei M\u00e4nnern eher mit hypoxie-bezogenen Mechanismen und bei Frauen eher mit schlaffragmentierenden Merkmalen verbunden ist.<br \/>(Castro-Diehl C, Alex R, Azarbarzin A, Zhang Y, Wellman A, Huang T, Sands S, Redline S. Associations of excessive sleepiness with sleep apnea physiological endo-phenotypes: the multi-ethnic study of atherosclerosis. Ann Am Thorac Soc. 2026;23(7):1067\u20131076)<br \/>","protected":false},"excerpt":{"rendered":"<p>\u00dcberm\u00e4\u00dfige Tagesschl\u00e4frigkeit (EDS) ist bei obstruktiver Schlafapnoe (OSA) ist mit bestimmten physiologischen Endotypen assoziiert und unterscheidet sich zwischen M\u00e4nnern und Frauen. In der bev\u00f6lkerungsbasierten Multi-Ethnic Study of Atherosclerosis (MESA) wurden 1783 Teilnehmer mit einem AHI > 5\/h (mittleres Alter 68,7 \u00b1 9,1 Jahre, 52 % Frauen) mittels Polysomnographie, Aktigraphie und Epworth-Schl\u00e4frigkeitsskala (ESS) untersucht. 14 % [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1542","post","type-post","status-publish","format-standard","hentry","category-allgemein"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"hein","author_link":"https:\/\/dr-holger-hein.de\/reloaded\/author\/hein\/"},"uagb_comment_info":0,"uagb_excerpt":"\u00dcberm\u00e4\u00dfige Tagesschl\u00e4frigkeit (EDS) ist bei obstruktiver Schlafapnoe (OSA) ist mit bestimmten physiologischen Endotypen assoziiert und unterscheidet sich zwischen M\u00e4nnern und Frauen. In der bev\u00f6lkerungsbasierten Multi-Ethnic Study of Atherosclerosis (MESA) wurden 1783 Teilnehmer mit einem AHI > 5\/h (mittleres Alter 68,7 \u00b1 9,1 Jahre, 52 % Frauen) mittels Polysomnographie, Aktigraphie und Epworth-Schl\u00e4frigkeitsskala (ESS) untersucht. 14 %&hellip;","_links":{"self":[{"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/posts\/1542","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/comments?post=1542"}],"version-history":[{"count":2,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/posts\/1542\/revisions"}],"predecessor-version":[{"id":1557,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/posts\/1542\/revisions\/1557"}],"wp:attachment":[{"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/media?parent=1542"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/categories?post=1542"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/tags?post=1542"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}