Zur Behandlung des Diabetes mellitus Typ II werden sogenannte GLP-1 Agonisten (Twinkretine) eingesetzt. Unter dieser Therapie nimmt das K\u00f6rpergewicht deutlich ab. Es wurde daher in zwei Studien mit 469 Patientin mit deutlichen \u00dcbergewicht (Body-Mass-Index > 35 k\/mxm, im Mittel 38,7 kg\/mxm, Alter im Mittel 48 52 Jahre, 1\/3 Frauen, Apnoe-Hypopnoe-Index (AHI) im Mittel 52\/h) \u00fcber 1 Jahr gepr\u00fcft, wie sich das Medikament auswirkt. Es wurde in einer Dosis von 10-15 mg Woche gespritzt. Der AHI verminderte sich unter dem Medikament um 25.3\/h bzw. um, 29,3\/h, unter Placebo um 5,5 bzw. 5,3h. eine genaue Betrachtung der ver\u00f6ffentlichten Kurven zeigt, dass die Name des Apnoe-Hypopnoe-Index parallel zu einer Gewichtsreduktion erfolgte, die im Mittel bei etwa 20% des vorigen K\u00f6rpergewichtes lag. Nebenwirkungen waren nicht selten, etwa 15-25% hatten gastointestinale Symptome verschiedner Art,: Diarrhoe, Obstipation odrer Erbrechen, unter dem Medikament mehr asl doppelt so h\u00e4ufig verglichen mit Placebo.
Meines Erachtens ist v.a. die Gewichtsreduktion der eigentliche Effekt. Zu beachten ist, dass die Studien nur an erheblich \u00fcbergewichtigen Personen durchgef\u00fchrt wurden. Es ist also keine grunds\u00e4tzliche Therapie bei Schlaf-Apnoe, sondern prim\u00e4r eine Gewichtsabnahme-Therapie.
(Malhotra A, Bednarik J, Chakladar S, Dunn JP, Weaver T, Grunstein R, Fietze I, Redline S, Azarbarzin A, Sands SA, Schwab RJ, Bunck MC. Tirzepatide for the treatment of obstructive sleep apnea: Rationale, design, and sample baseline characteristics of the SURMOUNT -OSA phase 3 trial. Contemp Clin Trials. 2024 Jun;141:107516. doi: 10.1016\/j.cct.2024.107516. Epub 2024 Mar 26. PMID: 38547961; PMCID: PMC11168245.<\/p>\n","protected":false},"excerpt":{"rendered":"
Zur Behandlung des Diabetes mellitus Typ II werden sogenannte GLP-1 Agonisten (Twinkretine) eingesetzt. Unter dieser Therapie nimmt das K\u00f6rpergewicht deutlich ab. Es wurde daher in zwei Studien mit 469 Patientin mit deutlichen \u00dcbergewicht (Body-Mass-Index > 35 k\/mxm, im Mittel 38,7 kg\/mxm, Alter im Mittel 48 52 Jahre, 1\/3 Frauen, Apnoe-Hypopnoe-Index (AHI) im Mittel 52\/h) \u00fcber […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1308","post","type-post","status-publish","format-standard","hentry","category-allgemein"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"hein","author_link":"https:\/\/dr-holger-hein.de\/reloaded\/author\/hein\/"},"uagb_comment_info":0,"uagb_excerpt":"Zur Behandlung des Diabetes mellitus Typ II werden sogenannte GLP-1 Agonisten (Twinkretine) eingesetzt. Unter dieser Therapie nimmt das K\u00f6rpergewicht deutlich ab. Es wurde daher in zwei Studien mit 469 Patientin mit deutlichen \u00dcbergewicht (Body-Mass-Index > 35 k\/mxm, im Mittel 38,7 kg\/mxm, Alter im Mittel 48 52 Jahre, 1\/3 Frauen, Apnoe-Hypopnoe-Index (AHI) im Mittel 52\/h) \u00fcber…","_links":{"self":[{"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/posts\/1308","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/comments?post=1308"}],"version-history":[{"count":4,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/posts\/1308\/revisions"}],"predecessor-version":[{"id":1313,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/posts\/1308\/revisions\/1313"}],"wp:attachment":[{"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/media?parent=1308"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/categories?post=1308"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/tags?post=1308"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}