<\/p>\n\n\n\n
29 Frauen und 10 M\u00e4nner mit obstruktiver Schlafapnoe (Alter: 51 \u00b1 11 Jahre, Body-Mass-Index 31 \u00b1 5 kg\/m2<\/sup>, Apnoe-Hypopnoe-Index 20 \u00b1 18\/h) wurden f\u00fcr einen Monat mit Placebo, 80mg Atomoxetine\/5mg Oxybutynin, (Ato-Oxy), 40\/5mg Ato-Oxy oder 40\/2,5mg Ato-Oxy behandelt. Vor und unter Therapie erfolgte eine Polysomnographie, und es wurden Daten zur Schl\u00e4frigkeit und Reaktionstestungen erhoben. Nebenwirkungen waren nur mild.<\/p>\n\n\n\n Unter der Therapie stieg der Puls gering an (8\u00b110\/min bzw. , 9\u00b114\/min). Der Blutdruck war unver\u00e4ndert, ebenso die subjektive Schl\u00e4frigkeit und die Aufmerksamkeitsleistungen. Der Apnoe-Hypopnoe-Index fiel um 50%,(minus 8,5\/h) ebenso das Ausma\u00df der Sauerstoffents\u00e4ttigungen. (Aishah A, Loffler KA, Toson B, Mukherjee S, Adams RJ, Altree TJ, Ainge-Allen HW, Yee BJ, Grunstein RR, Carberry JC, Eckert DJ. One Month Dosing of Atomoxetine plus Oxybutynin in Obstructive Sleep Apnea: A Randomized, Placebo-controlled Trial. Ann Am Thorac Soc. 2022 Dec 20. doi: 10.1513\/AnnalsATS.202206-492OC. Epub ahead of print. PMID: 36538809.)<\/p>\n\n\n\n Kommt eine medikament\u00f6se Therapie der obstruktiven Schlafapnoe ?\u2013 Teil 2<\/p>\n\n\n\n 6 Frauen und 12 M\u00e4nner (Alter: 54 \u00b1 14 Jahre, Body-Mass-Index 32 \u00b1 7 kg\/m2<\/sup>) erhielten eine Nacht Placebo oder 34 mg Pimavanserin bzw. vice versa , der Apnoe-Hypopnoe-Index fiel von 31\u00b1 29\/h auf 18\u00b1 40\/h). Die Arousal-Schwelle lag unter Pimavanserin h\u00f6her. (Messineo L, Gell L, Calianese N, Sofer T, Vena D, Azarbarzin A, Labarca G, Taranto-Montemurro L, Yang HC, Wang TY, Kim M, Smith H, White D, Sands S, Wellman A. Effect of Pimavanserin on the Respiratory Arousal Threshold from Sleep: A Randomized Trial. Ann Am Thorac Soc. 2022 Dec;19(12):2062-2069. doi: 10.1513\/AnnalsATS.202205-419OC. PMID: 35947827; PMCID: PMC9743476)<\/p>\n","protected":false},"excerpt":{"rendered":" 29 Frauen und 10 M\u00e4nner mit obstruktiver Schlafapnoe (Alter: 51 \u00b1 11 Jahre, Body-Mass-Index 31 \u00b1 5 kg\/m2, Apnoe-Hypopnoe-Index 20 \u00b1 18\/h) wurden f\u00fcr einen Monat mit Placebo, 80mg Atomoxetine\/5mg Oxybutynin, (Ato-Oxy), 40\/5mg Ato-Oxy oder 40\/2,5mg Ato-Oxy behandelt. Vor und unter Therapie erfolgte eine Polysomnographie, und es wurden Daten zur Schl\u00e4frigkeit und Reaktionstestungen erhoben. Nebenwirkungen […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1137","post","type-post","status-publish","format-standard","hentry","category-allgemein"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"hein","author_link":"https:\/\/dr-holger-hein.de\/reloaded\/author\/hein\/"},"uagb_comment_info":0,"uagb_excerpt":"29 Frauen und 10 M\u00e4nner mit obstruktiver Schlafapnoe (Alter: 51 \u00b1 11 Jahre, Body-Mass-Index 31 \u00b1 5 kg\/m2, Apnoe-Hypopnoe-Index 20 \u00b1 18\/h) wurden f\u00fcr einen Monat mit Placebo, 80mg Atomoxetine\/5mg Oxybutynin, (Ato-Oxy), 40\/5mg Ato-Oxy oder 40\/2,5mg Ato-Oxy behandelt. Vor und unter Therapie erfolgte eine Polysomnographie, und es wurden Daten zur Schl\u00e4frigkeit und Reaktionstestungen erhoben. Nebenwirkungen…","_links":{"self":[{"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/posts\/1137","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/comments?post=1137"}],"version-history":[{"count":1,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/posts\/1137\/revisions"}],"predecessor-version":[{"id":1138,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/posts\/1137\/revisions\/1138"}],"wp:attachment":[{"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/media?parent=1137"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/categories?post=1137"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dr-holger-hein.de\/reloaded\/wp-json\/wp\/v2\/tags?post=1137"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}